In a patient taking Erythromycin, the dose of Livalo should be restricted to:
a. 1 mg per day.
b. 5 mg per day.
c. 10 mg per day.
d. 25 mg per day.
e. 50 mg per day.
Answer: a. Pitavastatin (Livalo) is an inhibitor of HMG-CoA reductase. It is a synthetic lipid-lowering agent for oral administration. Each film-coated tablet of Pitavastatin (Livalo) contains1 mg. 2 mg or 4 mg Pitavastatin.
It is indicated as an adjunctive therapy to diet to reduce elevated total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), apolipoprotein B (Apo B), triglycerides (TG), and to increase HDL-C in adult patients with primary hyperlipidemia or mixed dyslipidemia.
Doses of Pitavastatin (Livalo) greater than 4 mg once daily were associated with an increased risk for severe myopathy in premarketing clinical studies. PAtients should not exceed 4 mg once daily dosing of Pitavastatin (Livalo). The dose range for Pitavastatin (Livalo) is 1 to 4 mg orally once daily at any time of the day with or without food. The recommended starting dose is 2 mg and the maximum dose is 4 mg.
In patients taking erythromycin, a dose of Pitavastatin (Livalo) 1 mg once daily should not be exceeded. In patients taking rifampin, a dose of Pitavastatin (Livalo) 2 mg once daily should not be exceeded.
Rhabdomyolysis with myoglobinuria and acute renal failure and myopathy (including myositis) and liver enzyme abnormalities are principal side effects of Pitavastatin (Livalo).
Try Naplex QBank. www.pharmacyexam.com