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pharmaceutical calculation book Reference Guide For Pharmaceutical Calculations- Third Edition (FPGEE, NAPLEX and PTCE)

Answers

1. (c) 1: 1000 generally interprets as 1 gm in 1000cc solution. The amount of lidocaine in 30cc of 1:1000 solution can be calculated as follows:

= 30 x 1/1000 = 0.03 gm = 30 milligrams.

2. (c) To solve this type of problem, we need to use alligation method.

75 20 (75%)

30

10 45 (10%)

Total parts 65 (30%)

To prepare 65 (30%) 20 parts (75%) need

To prepare 500 (30%) ?

= 500 x 20/65 = 153.84cc (75%) alcohol

If we mixed 153.84 cc of 75% alcohol with 346.16cc [500cc - 153.84] of 10% alcohol, then we can get 500cc of 30% alcohol solution.

3.(b) Amount of Hydrocortisone in 60 gm, 1%

= 60/100  = 0.6 gm of hydrocortisone.

Amount of hydrocortisone in 80 gm, 2.5%

= 80 x 2.5/100 = 2 gm hydrocortisone

% amount of hydrocortisone in final mixture

= 100 x 2.6 (2gm + 0.6gm)/140 (80gm + 60gm)

= 1.85% w/w.

4. (d) 1000 tablets of Risperdal 1mg cost $ 2250. The % mark up on prescription is 20%.

Therefore retail price of 1000 tablets would be

= 120 x 2250/100 = $ 2700 ** For each $ 100 cost = $120 retail cost**

Price for 30 tablet would be

= 30 x 2700/1000 = $ 81

5. (c) A pH of the solution can be found by the following formula:

pH = pKa + log ionize/unionize

= 2.2 + log 103

= 2.2 + 3

= 5.2

6. (c) 0.06cc. According to Fried’s rule

= age in months/150 x adult dose

= 15 x 325/150 = 32.5 mg

The dropper is calibrated to deliver 325 mg of Iron sulfate in 0.6 cc, therefore

= 0.6 x 32.5/325 = 0.06cc

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