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ANSWER
1
(b) Benzyl alcohol is classified as a preservative.
Preservatives prevent the growth of microorganisms
and prevent deterioration of pharmaceutical dosage
forms. The ideal preservative must have the following
characteristics:
It
must be effective against a broad spectrum of microorganisms.
It must be stable for the lifetime of the product.
It must be nontoxic, soluble, palatable in test and
odor and compatible with other ingredients in the
formulation.
Commonly
used preservatives:
*
phenol * benzoic acid
* benzyl alcohol * chlorobutanol
* thiomersal * benzalkonium
* cresol * cetylpyridinium
ANSWER
2
(c) Cold cream is an example of W/O emulsion. It is
a biphasic liquid dosage form, in which disperse phase
and the dispersion medium are liquids. Emulsion is
classified by five different categories:
Water
in Oil (W/O) : Oil is continuous phase and water is
a disperse phase, i.e. lotions and liniments.
Oil
in water (O/W) : Water is continuous phase and oil
is a dispersed phase i.e. most of the oral emulsions
to unmask the oil taste of a medication.
Microemulsion
: Unlike emulsions, microemulsion is a transparent
with a small particle size. It is believed to be thermodynamically
stable. The particle size of microemulsion lies between
10 to 200 nm. It is generally used for the solubilization
of the drug in pharmaceutical dosage form.
Nanoparticles
: As the name suggests, the particle size of this
kind of emulsion is limited to nanograms. They are
useful for the preparation of globulins and toxoids.
Tetanus toxoid and human immunoglobulin G are examples
of nanoparticles emulsion.
Multiple
emulsions : Water in Oil in ware (W/O/W), Oil in water
in Oil (O/W/O). The w/o/w emulsions are generally
more preferable for preparation of various pharmaceutical
dosage forms. They are used to prolong the duration
of action of various drugs, to localize drug in the
body and to prepare cosmetics.
ANSWER
3
(b) Sucrose is an example of Oligosaccharide. It consists
of a short chain of monosaccharide. It consists of
one molecule of glucose and one molecule of fructose.Carbohydrates
can be divided into three categories : Monosaccharide,
Oligosaccharide and Polysaccharide.
Monosaccharides
: They are simple sugar such as glucose and fructose.
Oligosaccharides
: Consists of a small chain of monosaccharides. i.e.
sucrose, maltose and lactose. They have to degraded
into simple sugar in order to be absorb from the intestine.
Degradation of sucrose gives one molecule of glucose
and fructose, degradation of maltose gives two molecules
of glucose, and degradation of lactose gives each
molecule of galactose and glucose.
Polysaccharides
: They consist of long chains of monosaccharides i.e.
starch and glycogen
ANSWER
4
(c) Uracil. It is a pyrimidine base that only found
on RNA.
Nucleotides
are the building blocks of the nucleic acid. Purines
and pyrimidines bases bind to ribose to form nucleoside,
which when binded to phosphoric acid forms the nucleotides.
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